RG Kalisch
Lead:
Prof. Dr Raffael Kalisch
Research Group Leader LIR, Director of Neuroimaging Center Mainz, Professor of Human Neuroimaging
Dr Benjamin Meyer, Postdoc
Papoula Petri-Romao, PhD student
Dr Lara Puhlmann, PhD student
Dr Kenneth S.L. Yuen, Postdoc
Elena Andres, Postdoc
Dogukan Koc, PhD student
Frédérique Maas, PhD student
Maximilian Lückel, PhD student
Matthias Zerban, PhD student
Lisanne van Houtum, Postdoc
Ajna Jansson, PhD student
We explore basic mechanisms of resilience in humans at the cognitive and neurofunctional levels and aim to formulate a comprehensive and unifying theory of resilience. We base this on a dynamic concept of resilience, which sees resilience as the result of an adaptation process to stressors. Thus, important tools are observational (MARP, LORA, DynaM-OBS, DynaCORE-L) and interventional (DynaM-INT, RESPOND-RCTs ) prospective longitudinal studies in which changes in biological and psychological functions are considered over time and as a function of stressor exposure and in their importance for the maintenance of mental health. Another important tool is computational analysis and modeling of these data sets. In addition, using methods from experimental psychology, brain imaging (MRI), brain stimulation (TMS, TUS), pharmacology, and psychophysiology, we are conducting laboratory studies on the cognitive and neural bases of identified resilience mechanisms such as extinction and cognitive emotion regulation.
- Longitudinal study "Longitudinal Resilience Assessment" (LORA)
- Longitudinal study "Mainz Resilience Project" (MARP)
- EU Horizon consortial project "Running in the Family" - understanding and predicting the intergenerational transmission of mental illness" (FAMILY)
- DEPARTMENTS OF DEFENCE AND VETERANS' AFFAIRS consortium project, Australia "A multi-system approach to needs and resilience resource profiling in the context of maritime operations"
- ERA-NET-Neuron consortial project "Pharmacological Augmentation of Stress Resilience - Proof-of-Principle" (PHASR-PP)
- Australian Research Council Discovery Project "Understanding Growth in Emotion Regulatory Flexibility in Emerging Adults"
- DFG project "Making extinction last: mechanistically understanding and causally probing the role of the ventromedial prefrontal cortex in extinction memory consolidation"
- Josep Maria Haro Abad, Psychiatry at University of Barcelona, Spanien
- Jose Luis Ayuso, Department of Psychiatry of Autonomous University of Madrid and La Princesa Teaching Hospital Madrid, Spanien
- Christian Beckmann, Radboud University Medical Centre (Radboudumc) · Department of Cognitive Neuroscience, Nijmegen, Niederlande
- Harald Binder, Institute for Medical Biometry and Informatics, University of Freiburg, Germany
- Richard Bryant, School of Psychology, University of New South Wales, Sydney, Australia
- Erno Hermans, Donders Institute, Radboud University Nijmegen, Netherlands
- Birgit Kleim, Institute of Psychology, University of Zurich, Switzerland
- Dorota Kobylinska, Faculty of Psychology, University of Warsaw, Poland
- Signe Mezinska, Faculty of Medicine, University of Latvia, Lettland
- Inez Myin-Germeys, Contextual Psychiatry, Catholic University Leuven, Belgium
- Andreas Reif, Department of Psychiatry and Psychotherapy, University Hospital, Goethe University Frankfurt a.M., Germany
- Karin Roelofs, Donders Institute, Radboud University Nijmegen, Netherlands
- Marit Sijbrandij, Faculty of Behavioural and Movement Sciences, Clinical Psychology, Free University of Amsterdam, Netherlands
- Jens Timmer, Institute for Physics, University of Freiburg, Germany
- Neeltje van Haren, Department of Child psychiatry at Erasmus MC Sophia Children’s Hospital Rotterdam, Niederlande
- Henrik Walter, Department of Psychiatry, Charité Berlin, Germany
- Monique Crane, School of Psychological Sciences, Macquarie University, Sydney, Australia
- Flurin Cathomas, Department of Psychiatry, University of Zurich, Switzerland
- Emma Sprooten, Radboud University Medical Centre (Radboudumc) · Department of Cognitive Neuroscience, Nijmegen, Niederlande
- Michael Plichta, Department of Psychiatry and Psychotherapy, University Hospital, Goethe University Frankfurt a.M., Germany
- Marta Marciniak, Erasmus School of Social and Behavioural Sciences, Erasmus University Rotterdam, Netherlands
- Ken-Ichiro Tsutsui, Graduate School of Life Sciences, Tohoku University, Sendai, Japan
- Katharina Schultebraucks, Data Science Institute at Columbia University, New York, USA
- Talma Hendler, Functional Brain Center, Tel Aviv University, Israel
- EU Horizon
- ERA-NET-Neuron
- DFG
Ahrens KF, Schenk C, Kollmann B, Puhlmann LMC, Neumann RJ, Schäfer SK, Reis D, Basten U, Weichert D, Fiebach CJ, Lutz B, Wessa M, Repple J, Lieb K, Tüscher O, Reif A, Kalisch R, Plichta MM. Resilience to major life events: Advancing trajectory modeling and resilience factor identification by controlling for background stressor exposure. Am Psychol. 2024 Nov;79(8):1076-1091. doi: 10.1037/amp0001315. PMID: 39531708.
>> Link to PubmedKalisch R, Russo SJ, Müller MB. Neurobiology and systems biology of stress resilience. Physiol Rev. 2024 Jul 1;104(3):1205-1263. doi: 10.1152/physrev.00042.2023. Epub 2024 Mar 14. PMID: 38483288; PMCID: PMC11381009.
>> Link to PubmedAndres E, Chuan-Peng H, Gerlicher AMV, Meyer B, Tüscher O, Kalisch R. Replication study on the role of dopamine-dependent prefrontal reactivations in human extinction memory retrieval. Nat Commun. 2024 Mar 27;15(1):2699. doi: 10.1038/s41467-024-46936-y. PMID: 38538636; PMCID: PMC10973457.
>> Link to PubmedPetri-Romão P, Engen H, Rupanova A, Puhlmann L, Zerban M, Neumann RJ, Malyshau A, Ahrens KF, Schick A, Kollmann B, Wessa M, Walker H, Plichta MM, Reif A, Chmitorz A, Tuescher O, Basten U, Kalisch R. Self-report assessment of Positive Appraisal Style (PAS): Development of a process-focused and a content-focused questionnaire for use in mental health and resilience research. PLoS One. 2024 Feb 2;19(2):e0295562. doi: 10.1371/journal.pone.0295562. PMID: 38306328; PMCID: PMC10836662.
>> Link to PubmedAyash S, Lingner T, Ramisch A, Ryu S, Kalisch R, Schmitt U, Müller MB. Fear circuit-based neurobehavioral signatures mirror resilience to chronic social stress in mouse. Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2205576120. doi: 10.1073/pnas.2205576120. Epub 2023 Apr 17. PMID: 37068238; PMCID: PMC10151471.
>> Link to PubmedKöber G, Pooseh S, Engen H, Chmitorz A, Kampa M, Schick A, Sebastian A, Tüscher O, Wessa M, Yuen KSL, Walter H, Kalisch R, Timmer J, Binder H (2022). Individualizing deep dynamic models for psychological resilience data. Sci Rep. 2022 May 16;12(1):8061. doi: 10.1038/s41598-022-11650-6
>> Link to PubmedSchäfer SK, Kunzler AM, Kalisch R, Tüscher O, Lieb K (2022). Trajectories of resilience and mental distress to global major disruptions. Trends Cogn Sci. 2022 Oct 24:S1364-6613(22)00238-8. doi: 10.1016/j.tics.2022.09.017. Online ahead of print
>> Link to PubmedKalisch R, Köber G, Binder H, Ahrens KF, Basten U, Chmitorz A, Choi KW, Fiebach CJ, Goldbach N, Neumann RJ, Kampa M, Kollmann B, Lieb K, Plichta MM, Reif A, Schick A, Sebastian A, Walter H, Wessa M, Yuen KSL, Tüscher O, Engen H (2021). The Frequent Stressor and Mental Health Monitoring-Paradigm: A Proposal for the Operationalization and Measurement of Resilience and the Identification of Resilience Processes in Longitudinal Observational Studies. Front Psychol. 12:710493.
>> Link to PubmedKöber G, Kalisch R, Puhlmann L, Chmitorz A, Schick A, Binder H (2021) Deep learning and differential equations for modeling changes in individual-level latent dynamics between observation periods. Biometrical Journal. 52. In press
>> Link to PubmedVeer et al (2021) Psycho-social factors associated with mental resilience in the Corona lockdown. Transl Psychiatry 11:67.
>> Link to PubmedChmitorz A, Kurth K, Mey LK, Wenzel M, Lieb K, Tüscher O, Kubiak T, Kalisch R (2020). Assessment of microstressors in adults: Questionnaire development and ecological validation of the Mainz Inventory of Microstressors. JMIR Ment Health 7(2):e14566.
>> Link to PubmedKampa M, Schick A, Sebastian A, Wessa M, Tüscher O, Kalisch R, Yuen K (2020). Replication of fMRI group activations in the neuroimaging battery for the Mainz Resilience Project (MARP). Neuroimage 204:116223.
>> Link to PubmedKalisch R*, Cramer AOJ*, Binder H, Fritz J, Leertouwer IJ, Lunansky G, Meyer B, Timmer J, Veer IM, van Harmelen A-L (2019) Deconstructing and reconstructing resilience: a dynamic network Approach. Persp Psych Sci, 14:765-7.
>> Link to PubmedGerlicher AMV, Tüscher O, Kalisch R. Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction. Nat Commun. 2018 Oct 16;9(1):4294. doi: 10.1038/s41467-018-06785-y. Erratum in: Nat Commun. 2019 Jan 23;10(1):471. doi: 10.1038/s41467-019-08399-4. PMID: 30327462; PMCID: PMC6191435.
>> Link to PubmedSalinas-Hernández XI, Vogel P, Betz S, Kalisch R, Sigurdsson T, Duvarci S. Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes. Elife. 2018 Nov 13;7:e38818. doi: 10.7554/eLife.38818. PMID: 30421719; PMCID: PMC6257816.
>> Link to PubmedKalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Diest IV, Harmelen AV, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017). The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1(11):784-790.
>> Link to PubmedHaaker J, Gaburro S, Sah A, Gartmann N, Lonsdorf TB, Meier K, Singewald N, Pape HC, Morellini F*, Kalisch R* (2013) Single dose of L-dopa makes extinction memories context-independent and prevents the return of fear. PNAS 110:E2428-36
>> Link to PubmedRaczka KA, Mechias ML, Gartmann N, Reif A, Deckert J, Pessiglione M, Kalisch R. Empirical support for an involvement of the mesostriatal dopamine system in human fear extinction. Transl Psychiatry. 2011 Jun 7;1(6):e12. doi: 10.1038/tp.2011.10. PMID: 22832428; PMCID: PMC3309464.
>> Link to PubmedEtkin A, Egner T, Kalisch R (2011) Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci 15:85-93.
>> Link to PubmedRaczka KA, Gartmann N, Mechias ML, Reif A, Buchel C, Deckert J, Kalisch R (2010) A neuropeptide S receptor variant associated with overinterpretation of fear reactions: a potential neurogenetic basis for catastrophizing. Mol Psychiatry 15:1067−1074. Corrigendum: 17:468.
>> Link to PubmedKalisch R (2009) The functional neuroanatomy of reappraisal: time matters. Neurosci Biobehav Rev 33:1215-26.
>> Link to PubmedPessiglione M, Schmidt L, Draganski B, Kalisch R, Lau H, Dolan RJ, Frith CD (2007) How the brain translates money into force: a neuroimaging study of subliminal motivation. Science 316:904−906.
>> Link to Pubmed